Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families
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Author
Takahashi, SakaeCui, Yu-hu
Kojima, Takuya
Han, Yong-hua
Zhou, Ru-lum
Kamioka, Masashi
Yu, Shun-ying
Matsuura, Masato
Matsushima, Eisuyke
Wilcox, Marsha
Arinami, Tadao
Shen, Yu-cun
Faraone, Stephen V.
Tsuang, Ming T.
Keyword
Genetics(clinical)schizophrenia; chromosome 22; D22S683; family-based association study; FBAT
Journal title
American Journal of Medical GeneticsDate Published
2003-06-13Publication Volume
120BPublication Issue
1Publication Begin page
11Publication End page
17
Metadata
Show full item recordAbstract
Several studies suggest that loci at chromosome 22q11.2-q13 might be linked to susceptibility to schizophrenia. Here we performed family-based association studies on chromosome 22q using 12 DNA microsatellite markers in African-American, European-American, and Chinese pedigrees. The marker D22S683 showed significant linkage and association with schizophrenia in not only the European-American sample but also in a combined sample (European-American and Chinese samples). Notably, D22S683 is located nearby and between D22S278 and D22S283, which have shown linkage and association to schizophrenia in prior reports. However, we found no significant association for the African-American sample. In conclusion, our data provide further support for the idea that the region around D22S683 contains a susceptibility gene for schizophrenia. © 2003 Wiley-Liss, Inc.Citation
Takahashi, S., Cui, Y.-h., Kojima, T., Han, Y.-h., Zhou, R.-l., Kamioka, M., Yu, S.-y., Matsuura, M., Matsushima, E., Wilcox, M., Arinami, T., Shen, Y.-c., Faraone, S.V. and Tsuang, M.T. (2003), Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families. Am. J. Med. Genet., 120B: 11-17. https://doi.org/10.1002/ajmg.b.20031DOI
10.1002/ajmg.b.20031ae974a485f413a2113503eed53cd6c53
10.1002/ajmg.b.20031
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