Show simple item record

dc.contributor.authorCloninger, C. Robert
dc.contributor.authorKaufmann, Charles A.
dc.contributor.authorFaraone, Stephen V.
dc.contributor.authorMalaspina, Dolores
dc.contributor.authorSvrakic, Dragan M.
dc.contributor.authorHarkavy-Friedman, Jill
dc.contributor.authorSuarez, Brian K.
dc.contributor.authorMatise, Tara C.
dc.contributor.authorShore, David
dc.contributor.authorLee, Hang
dc.contributor.authorHampe, Carol L.
dc.contributor.authorWynne, Debra
dc.contributor.authorDrain, Caroline
dc.contributor.authorMarkel, Paul D.
dc.contributor.authorZambuto, Christopher T.
dc.contributor.authorSchmitt, Karin
dc.contributor.authorTsuang, Ming T.
dc.date.accessioned2021-06-28T19:03:12Z
dc.date.available2021-06-28T19:03:12Z
dc.date.issued1998-07-10
dc.identifier.citationCloninger, C. R., Kaufmann, C. A., Faraone, S. V., Malaspina, D., Svrakic, D. M., Harkavy‐Friedman, J., ... & Tsuang, M. T. (1998). Genome‐wide search for schizophrenia susceptibility loci: The NIMH genetics initiative and millennium consortium. American journal of medical genetics, 81(4), 275-281.en_US
dc.identifier.issn0148-7299
dc.identifier.eissn1096-8628
dc.identifier.doi10.1002/(sici)1096-8628(19980710)81:4<275::aid-ajmg1>3.0.co;2-t
dc.identifier.urihttp://hdl.handle.net/20.500.12648/1776
dc.description.abstractchizophrenia has a complex pattern of inheritance, indicative of interactions among multiple genes and environmental factors. The detection and replication of specific susceptibility loci for such complex disorders are facilitated by the availability of large samples of affected sib pairs and their nuclear families, along with standardized assessment and systematic ascertainment procedures. The NIMH Genetics Initiative on Schizophrenia, a multisite collaborative study, was established as a national resource with a centralized clinical data base and cell repository. The Millennium Schizophrenia Consortium has completed a genome-wide scan to detect susceptibility loci for schizophrenia in 244 individuals from the nuclear families of 92 independent pairs of schizophrenic sibs ascertained by the NIMH Genetics Initiative. The 459 marker loci used in the scan were spaced at 10-cM intervals on average. Individuals of African descent were higher than those of European descent in their average heterozygosity (79% vs. 76%, P < .0001) and number of alleles per marker (9.2 vs. 8.4, P < .0001). Also, the allele frequencies of 73% of the marker loci differed significantly (P < .01) between individuals of European and African ancestry. However, regardless of ethnic background, this sample was largely comprised of schizophrenics with more than a decade of psychosis associated with pervasive social and occupational impairment. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:275–281, 1998. © 1998 Wiley-Liss, Inc.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://doi.wiley.com/10.1002/tdm_license_1.1
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGenetics(clinical)en_US
dc.subjectschizophrenia; genetics; linkage; family studyen_US
dc.titleGenome-wide search for schizophrenia susceptibility loci: The NIMH genetics initiative and millennium consortiumen_US
dc.typeArticleen_US
dc.source.journaltitleAmerican Journal of Medical Geneticsen_US
dc.source.volume81
dc.source.issue4
dc.source.beginpage275
dc.source.endpage281
dc.description.versionVoRen_US
refterms.dateFOA1999-01-24T00:00:00Z
dc.description.institutionUpstate Medical Universityen_US
dc.description.departmentPsychaitryen_US
dc.description.degreelevelN/Aen_US


This item appears in the following Collection(s)

Show simple item record