Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure
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Author
Hoogman, MartineRooij, Daan
Klein, Marieke
Boedhoe, Premika
Ilioska, Iva
Li, Ting
Patel, Yash
Postema, Merel C.
Zhang‐James, Yanli
Anagnostou, Evdokia
Arango, Celso
Auzias, Guillaume
Banaschewski, Tobias
Bau, Claiton H. D.
Behrmann, Marlene
Bellgrove, Mark A.
Brandeis, Daniel
Brem, Silvia
Busatto, Geraldo F.
Calderoni, Sara
Calvo, Rosa
Castellanos, Francisco X.
Coghill, David
Conzelmann, Annette
Daly, Eileen
Deruelle, Christine
Dinstein, Ilan
Durston, Sarah
Ecker, Christine
Ehrlich, Stefan
Epstein, Jeffery N.
Fair, Damien A.
Fitzgerald, Jacqueline
Freitag, Christine M.
Frodl, Thomas
Gallagher, Louise
Grevet, Eugenio H.
Haavik, Jan
Hoekstra, Pieter J.
Janssen, Joost
Karkashadze, Georgii
King, Joseph A.
Konrad, Kerstin
Kuntsi, Jonna
Lazaro, Luisa
Lerch, Jason P.
Lesch, Klaus‐Peter
Louza, Mario R.
Luna, Beatriz
Mattos, Paulo
McGrath, Jane
Muratori, Filippo
Murphy, Clodagh
Nigg, Joel T.
Oberwelland‐Weiss, Eileen
O'Gorman Tuura, Ruth L.
O'Hearn, Kirsten
Oosterlaan, Jaap
Parellada, Mara
Pauli, Paul
Plessen, Kerstin J.
Ramos‐Quiroga, J. Antoni
Reif, Andreas
Reneman, Liesbeth
Retico, Alessandra
Rosa, Pedro G. P.
Rubia, Katya
Shaw, Philip
Silk, Tim J.
Tamm, Leanne
Vilarroya, Oscar
Walitza, Susanne
Jahanshad, Neda
Faraone, Stephen V.
Francks, Clyde
Heuvel, Odile A.
Paus, Tomas
Thompson, Paul M.
Buitelaar, Jan K.
Franke, Barbara
Keyword
AnatomyRadiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Neurology
Clinical Neurology
Journal title
Human Brain MappingDate Published
2020-05-18
Metadata
Show full item recordAbstract
Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case–control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case–control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.DOI
10.1002/hbm.25029ae974a485f413a2113503eed53cd6c53
10.1002/hbm.25029
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