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dc.contributor.authorDemontis, Ditte
dc.contributor.authorWalters, Raymond K.
dc.contributor.authorRajagopal, Veera M.
dc.contributor.authorWaldman, Irwin D.
dc.contributor.authorGrove, Jakob
dc.contributor.authorAls, Thomas D.
dc.contributor.authorDalsgaard, Søren
dc.contributor.authorRibasés, Marta
dc.contributor.authorBybjerg-Grauholm, Jonas
dc.contributor.authorBækvad-Hansen, Maria
dc.contributor.authorWerge, Thomas
dc.contributor.authorNordentoft, Merete
dc.contributor.authorMors, Ole
dc.contributor.authorMortensen, Preben Bo
dc.contributor.authorCormand, Bru
dc.contributor.authorHougaard, David M.
dc.contributor.authorNeale, Benjamin M.
dc.contributor.authorFranke, Barbara
dc.contributor.authorFaraone, Stephen V.
dc.contributor.authorBørglum, Anders D.
dc.date.accessioned2021-03-31T18:24:15Z
dc.date.available2021-03-31T18:24:15Z
dc.date.issued2021-01-25
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-020-20443-2
dc.identifier.pii20443
dc.identifier.urihttp://hdl.handle.net/20.500.12648/1683
dc.description.abstractAttention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10-10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectGeneral Biochemistry, Genetics and Molecular Biologyen_US
dc.subjectGeneral Physics and Astronomyen_US
dc.subjectGeneral Chemistryen_US
dc.titleRisk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorderen_US
dc.typeArticleen_US
dc.source.journaltitleNature Communicationsen_US
dc.source.volume12
dc.source.issue1
dc.description.versionNAen_US
refterms.dateFOA2021-03-31T18:24:16Z
dc.description.institutionUpstate Medical Universityen_US
dc.description.departmentPsychiatryen_US
dc.description.degreelevelVoRen_US


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