Association between maternal mRNA covid-19 vaccination in early pregnancy and major congenital anomalies in offspring: population based cohort study with sibling matched analysis
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Author
Jorgensen, Sarah C JDrover, Samantha S M
Fell, Deshayne B
Austin, Peter C
D'Souza, Rohan
Guttmann, Astrid
Buchan, Sarah A
Wilson, Sarah E
Nasreen, Sharifa
Brown, Kevin A
Schwartz, Kevin L
Tadrous, Mina
Wilson, Kumanan
Kwong, Jeffrey C
Journal title
BMJ MedicineDate Published
2024-09-16Publication Volume
3Publication Issue
1Publication Begin page
e000743
Metadata
Show full item recordAbstract
Objective: To examine the association between maternal mRNA covid-19 vaccination during the first trimester of pregnancy and the prevalence of major congenital anomalies in offspring. Design: Population based cohort study with sibling matched analysis. Setting: Multiple health administrative databases, linked and analysed at ICES, an independent, non-profit research institute that collects and analyses healthcare and demographic data, Ontario, Canada, from 16 October 2021 to 1 May 2023. Population: 174 296 singleton live births >20 weeks' gestation with an expected birth date between 16 October 2021 and 1 May 2023: 34 181 (20%) born to mothers who received one or two doses of an mRNA covid-19 vaccine in the first trimester and 34 951 (20%) born to mothers who did not receive a vaccine before or during pregnancy. The sibling matched analysis included 13 312 infants exposed to a covid-19 vaccine in the first trimester and 15 089 matched older siblings with the same mother, with an expected birth date after 16 October 2016 and no reported in utero exposure to a covid-19 vaccine. Main outcome measures: Major congenital anomalies, overall and grouped by specific organ systems, diagnosed within 28 days of birth. Results: Major congenital anomalies were present in 832 (24.3 per 1000 live births) infants exposed to an mRNA covid-19 vaccine in the first trimester compared with 927 (26.5 per 1000 live births) infants not exposed to a vaccine, resulting in an adjusted prevalence ratio of 0.89 (95% confidence interval (CI) 0.79 to 1.01). Major congenital anomalies were present in 283 (21.3 per 1000 live births) and 343 (22.7 per 1000 live births) infants exposed to an mRNA covid-19 vaccine in the first trimester and their older siblings not exposed to a vaccine, respectively (adjusted prevalence ratio 0.91, 95% CI 0.77 to 1.07). First trimester vaccination was not associated with an increase in major congenital anomalies grouped by specific organ system in the primary or sibling matched analyses. Results were similar across a range of subgroup and sensitivity analyses. Conclusions: In this large population based cohort study and sibling matched analysis, mRNA covid-19 vaccination during the first trimester of pregnancy was not associated with an increase in major congenital anomalies in offspring, overall or grouped by organ system.Citation
Jorgensen SCJ, Drover SSM, Fell DB, Austin PC, D'Souza R, Guttmann A, Buchan SA, Wilson SE, Nasreen S, Brown KA, Schwartz KL, Tadrous M, Wilson K, Kwong JC; Canadian Immunization Research Network (CIRN) Provincial Collaborative Network (PCN) Investigators. Association between maternal mRNA covid-19 vaccination in early pregnancy and major congenital anomalies in offspring: population based cohort study with sibling matched analysis. BMJ Med. 2024 Sep 16;3(1):e000743. doi: 10.1136/bmjmed-2023-000743. PMID: 39574424; PMCID: PMC11579536.DOI
10.1136/bmjmed-2023-000743ae974a485f413a2113503eed53cd6c53
10.1136/bmjmed-2023-000743
Scopus Count
Collections
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/4.0/
Related articles
- COVID-19 Vaccination in the First Trimester and Major Structural Birth Defects Among Live Births.
- Authors: Kharbanda EO, DeSilva MB, Lipkind HS, Romitti PA, Zhu J, Vesco KK, Boyce TG, Daley MF, Fuller CC, Getahun D, Jackson LA, Williams JTB, Zerbo O, Weintraub ES, Vazquez-Benitez G
- Issue date: 2024 Aug 1
- Reductions in stillbirths and preterm birth in COVID-19-vaccinated women: a multicenter cohort study of vaccination uptake and perinatal outcomes.
- Authors: Hui L, Marzan MB, Rolnik DL, Potenza S, Pritchard N, Said JM, Palmer KR, Whitehead CL, Sheehan PM, Ford J, Mol BW, Walker SP
- Issue date: 2023 May
- Newborn and Early Infant Outcomes Following Maternal COVID-19 Vaccination During Pregnancy.
- Authors: Jorgensen SCJ, Drover SSM, Fell DB, Austin PC, D'Souza R, Guttmann A, Buchan SA, Wilson SE, Nasreen S, Schwartz KL, Tadrous M, Wilson K, Kwong JC
- Issue date: 2023 Dec 1
- Risk for Congenital Malformation With H1N1 Influenza Vaccine: A Cohort Study With Sibling Analysis.
- Authors: Ludvigsson JF, Ström P, Lundholm C, Cnattingius S, Ekbom A, Örtqvist Å, Feltelius N, Granath F, Stephansson O
- Issue date: 2016 Dec 20
- Association of BNT162b2 COVID-19 Vaccination During Pregnancy With Neonatal and Early Infant Outcomes.
- Authors: Goldshtein I, Steinberg DM, Kuint J, Chodick G, Segal Y, Shapiro Ben David S, Ben-Tov A
- Issue date: 2022 May 1