Association between adolescent alcohol use and cognitive function in young adulthood: A co‐twin comparison study
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Author
Cooke, Megan E.Stephenson, Mallory
Brislin, Sarah J.
Latvala, Antti
Barr, Peter B.
Piirtola, Maarit
Vuoksimaa, Eero
Rose, Richard J.
Kaprio, Jaakko
Dick, Danielle M.
Salvatore, Jessica E.
Journal title
AddictionDate Published
2024-08-06Publication Volume
119Publication Issue
11Publication Begin page
1947Publication End page
1955
Metadata
Show full item recordAbstract
Background and aims: Studies on adolescent alcohol use and cognition are often unable to separate the potential causal effects of alcohol use on cognition from shared etiological influences, including genetic influences or other substance use comorbidities also known to be associated with cognition, such as nicotine use. The present study aimed to fill this gap and clarify the relationship between adolescent alcohol use and young adult cognition by accounting for both measured and unmeasured confounders. Design: A random effects model accounting for nesting in families was used to control for measured confounders. Next, co-twin comparisons were conducted within the full sample and in monozygotic twin pairs (MZ) to control for unmeasured genetic and environmental confounders shared by co-twins. Participants/setting: Participants were 812 individuals (58.6% female, 361 complete pairs, 146 MZ pairs) from the longitudinal FinnTwin12 study in Finland. Measurements: Adolescent alcohol use was indexed with measures of frequency of use and intoxication averaged across ages 14 and 17. Cognitive outcomes were measured at average age 22 and included Trail Making Test, California Stroop test, Wechsler Adult Intelligence subtests (Vocabulary, Block Design, Digit Symbol), Digit Span subtest of Wechsler Memory Scale, Mental Rotation Test and Object Location Memory test. Covariates included sex, parental education, general cognitive ability, current alcohol use and nicotine use. Findings: Greater frequency of alcohol use and frequency of intoxication across adolescence was associated with decreased vocabulary scores in the co-twin control [freq: stnd beta = -0.12, 95% confidence interval (CI) = -0.234, -0.013] and MZ only co-twin control models (freq: stnd beta = -0.305, 95% CI = -0.523, -0.087; intox: stnd beta = -0.301, 95% CI = -0.528, -0.074). Conclusions: In Finland, there appears to be little evidence that adolescent alcohol use causes cognitive deficits in young adulthood, except modest evidence for association of higher adolescent alcohol use with lower young adult vocabulary scores.Citation
Cooke ME, Stephenson M, Brislin SJ, Latvala A, Barr PB, Piirtola M, Vuoksimaa E, Rose RJ, Kaprio J, Dick DM, Salvatore JE. Association between adolescent alcohol use and cognitive function in young adulthood: A co-twin comparison study. Addiction. 2024 Nov;119(11):1947-1955. doi: 10.1111/add.16629. Epub 2024 Aug 6. PMID: 39108000.DOI
10.1111/add.16629ae974a485f413a2113503eed53cd6c53
10.1111/add.16629
Scopus Count
Collections
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
Related articles
- Sex differences in genetic and environmental contributions to alcohol consumption from early adolescence to young adulthood.
- Authors: Seglem KB, Waaktaar T, Ask H, Torgersen S
- Issue date: 2016 Jul
- Which adolescent factors predict alcohol misuse in young adulthood? A co-twin comparisons study.
- Authors: Stephenson M, Barr P, Ksinan A, Aliev F, Latvala A, Viken R, Rose R, Kaprio J, Dick D, Salvatore JE
- Issue date: 2020 May
- Tests of the effects of adolescent early alcohol exposures on adult outcomes.
- Authors: Irons DE, Iacono WG, McGue M
- Issue date: 2015 Feb
- Genetic influences on alcohol use behaviors have diverging developmental trajectories: a prospective study among male and female twins.
- Authors: Meyers JL, Salvatore JE, Vuoksimaa E, Korhonen T, Pulkkinen L, Rose RJ, Kaprio J, Dick DM
- Issue date: 2014 Nov
- Genetic origins of the association between verbal ability and alcohol dependence symptoms in young adulthood.
- Authors: Latvala A, Tuulio-Henriksson A, Dick DM, Vuoksimaa E, Viken RJ, Suvisaari J, Kaprio J, Rose RJ
- Issue date: 2011 Mar