Stem cell‐derived cardiomyocyte heterogeneity confounds electrophysiological insights
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Journal title
The Journal of PhysiologyDate Published
2024-05-09Publication Volume
602Publication Issue
20Publication Begin page
5155Publication End page
5162
Metadata
Show full item recordAbstract
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offer potential as an in vitro model for studying drug cardiotoxicity and patient-specific cardiovascular disease. The inherent electrophysiological heterogeneity of these cells limits the depth of insights that can be drawn from well-designed experiments. In this review, we provide our perspective on some sources and the consequences of iPSC-CM heterogeneity. We demonstrate the extent of heterogeneity in the literature and explain how such heterogeneity is exacerbated by patch-clamp experimental artifacts in the manual and automated set-up. Finally, we discuss how this heterogeneity, caused by both intrinsic and extrinsic factors, limits our ability to build digital twins of patient-derived cardiomyocytes.Citation
Clark AP, Krogh-Madsen T, Christini DJ. Stem cell-derived cardiomyocyte heterogeneity confounds electrophysiological insights. J Physiol. 2024 Oct;602(20):5155-5162. doi: 10.1113/JP284618. Epub 2024 May 9. PMID: 38723234; PMCID: PMC11493526.DOI
10.1113/jp284618ae974a485f413a2113503eed53cd6c53
10.1113/jp284618
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/4.0/