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dc.contributor.authorLeal-Campanario, Rocio
dc.contributor.authorAlarcon-Martinez, Luis
dc.contributor.authorRieiro, Hector
dc.contributor.authorMartinez-Conde, Susana
dc.contributor.authorAlarcon-Martinez, Tugba
dc.contributor.authorZhao, Xiuli
dc.contributor.authorLaMee, Jonathan
dc.contributor.authorPopp, Pamela J. Osborn
dc.contributor.authorCalhoun, Michael E.
dc.contributor.authorArribas, Juan I.
dc.contributor.authorSchlegel, Alexander A.
dc.contributor.authorStasi, Leandro L. Di
dc.contributor.authorRho, Jong M.
dc.contributor.authorInge, Landon
dc.contributor.authorOtero-Millan, Jorge
dc.contributor.authorTreiman, David M.
dc.contributor.authorMacknik, Stephen L.
dc.date.accessioned2024-09-30T16:02:30Z
dc.date.available2024-09-30T16:02:30Z
dc.date.issued2017-02-27
dc.identifier.citationLeal-Campanario R, Alarcon-Martinez L, Rieiro H, Martinez-Conde S, Alarcon-Martinez T, Zhao X, LaMee J, Popp PJ, Calhoun ME, Arribas JI, Schlegel AA, Stasi LL, Rho JM, Inge L, Otero-Millan J, Treiman DM, Macknik SL. Abnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsy. Sci Rep. 2017 Feb 27;7:43276. doi: 10.1038/srep43276. PMID: 28240297; PMCID: PMC5327474.en_US
dc.identifier.eissn2045-2322
dc.identifier.doi10.1038/srep43276
dc.identifier.pmid28240297
dc.identifier.piiBFsrep43276
dc.identifier.urihttp://hdl.handle.net/20.500.12648/15550
dc.description.abstractSeizure-driven brain damage in epilepsy accumulates over time, especially in the hippocampus, which can lead to sclerosis, cognitive decline, and death. Excitotoxicity is the prevalent model to explain ictal neurodegeneration. Current labeling technologies cannot distinguish between excitotoxicity and hypoxia, however, because they share common molecular mechanisms. This leaves open the possibility that undetected ischemic hypoxia, due to ictal blood flow restriction, could contribute to neurodegeneration previously ascribed to excitotoxicity. We tested this possibility with Confocal Laser Endomicroscopy (CLE) and novel stereological analyses in several models of epileptic mice. We found a higher number and magnitude of NG2+ mural-cell mediated capillary constrictions in the hippocampus of epileptic mice than in that of normal mice, in addition to spatial coupling between capillary constrictions and oxidative stressed neurons and neurodegeneration. These results reveal a role for hypoxia driven by capillary blood flow restriction in ictal neurodegeneration.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.urlhttps://www.nature.com/articles/srep43276en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAbnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsyen_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleScientific Reportsen_US
dc.source.volume7
dc.source.issue1
dc.description.versionVoRen_US
refterms.dateFOA2024-09-30T16:02:31Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentNeurologyen_US
dc.description.departmentOphthalmologyen_US
dc.description.departmentPhysiology and Pharmacologyen_US
dc.description.departmentLaboratory of Translational Neuroscienceen_US
dc.description.degreelevelN/Aen_US


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