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dc.contributor.authorJu, Niansheng
dc.contributor.authorLi, Yang
dc.contributor.authorLiu, Fang
dc.contributor.authorJiang, Hongfei
dc.contributor.authorMacknik, Stephen L.
dc.contributor.authorMartinez-Conde, Susana
dc.contributor.authorTang, Shiming
dc.date.accessioned2024-09-23T18:09:28Z
dc.date.available2024-09-23T18:09:28Z
dc.date.issued2020-02-04
dc.identifier.citationJu N, Li Y, Liu F, Jiang H, Macknik SL, Martinez-Conde S, Tang S. Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons. Nat Commun. 2020 Feb 4;11(1):697. doi: 10.1038/s41467-020-14501-y. PMID: 32019929; PMCID: PMC7000673.en_US
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-020-14501-y
dc.identifier.pmid32019929
dc.identifier.pii14501
dc.identifier.urihttp://hdl.handle.net/20.500.12648/15524
dc.description.abstractThe integration of synaptic inputs onto dendrites provides the basis for neuronal computation. Whereas recent studies have begun to outline the spatial organization of synaptic inputs on individual neurons, the underlying principles related to the specific neural functions are not well understood. Here we perform two-photon dendritic imaging with a genetically-encoded glutamate sensor in awake monkeys, and map the excitatory synaptic inputs on dendrites of individual V1 superficial layer neurons with high spatial and temporal resolution. We find a functional integration and trade-off between orientation-selective and color-selective inputs in basal dendrites of individual V1 neurons. Synaptic inputs on dendrites are spatially clustered by stimulus feature, but functionally scattered in multidimensional feature space, providing a potential substrate of local feature integration on dendritic branches. Furthermore, apical dendrite inputs have larger receptive fields and longer response latencies than basal dendrite inputs, suggesting a dominant role for apical dendrites in integrating feedback in visual information processing.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.urlhttps://www.nature.com/articles/s41467-020-14501-yen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSpatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neuronsen_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleNature Communicationsen_US
dc.source.volume11
dc.source.issue1
dc.description.versionVoRen_US
refterms.dateFOA2024-09-23T18:09:29Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPhysiology and Pharmacologyen_US
dc.description.departmentNeurologyen_US
dc.description.departmentOphthalmologyen_US
dc.description.departmentLaboratory of Translational Neuroscienceen_US
dc.description.degreelevelN/Aen_US
dc.identifier.issue1en_US


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