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dc.contributor.authorJorgensen, Sarah C J
dc.contributor.authorHernandez, Alejandro
dc.contributor.authorFell, Deshayne B
dc.contributor.authorAustin, Peter C
dc.contributor.authorD’Souza, Rohan
dc.contributor.authorGuttmann, Astrid
dc.contributor.authorBrown, Kevin A
dc.contributor.authorBuchan, Sarah A
dc.contributor.authorGubbay, Jonathan B
dc.contributor.authorNasreen, Sharifa
dc.contributor.authorSchwartz, Kevin L
dc.contributor.authorTadrous, Mina
dc.contributor.authorWilson, Kumanan
dc.contributor.authorKwong, Jeffrey C
dc.date.accessioned2024-06-17T18:17:43Z
dc.date.available2024-06-17T18:17:43Z
dc.date.issued2023-02-08
dc.identifier.citationJorgensen SCJ, Hernandez A, Fell DB, Austin PC, D'Souza R, Guttmann A, Brown KA, Buchan SA, Gubbay JB, Nasreen S, Schwartz KL, Tadrous M, Wilson K, Kwong JC; Canadian Immunization Research Network (CIRN) Provincial Collaborative Network (PCN) Investigators. Maternal mRNA covid-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants: test negative design study. BMJ. 2023 Feb 8;380:e074035. doi: 10.1136/bmj-2022-074035. PMID: 36754426; PMCID: PMC9903336.en_US
dc.identifier.eissn1756-1833
dc.identifier.doi10.1136/bmj-2022-074035
dc.identifier.pmid36754426
dc.identifier.pii10.1136/bmj-2022-074035
dc.identifier.urihttp://hdl.handle.net/20.500.12648/14965
dc.description.abstractObjective: To estimate the effectiveness of maternal mRNA covid-19 vaccination during pregnancy against delta and omicron severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and hospital admission in infants. Design: Test negative design study. Setting: Community and hospital testing in Ontario, Canada. Participants: Infants younger than six months of age, born between 7 May 2021 and 31 March 2022, who were tested for SARS-CoV-2 between 7 May 2021 and 5 September 2022. Intervention: Maternal mRNA covid-19 vaccination during pregnancy. Main outcome measures: Laboratory confirmed delta or omicron infection or hospital admission of the infant. Multivariable logistic regression estimated vaccine effectiveness, with adjustments for clinical and sociodemographic characteristics associated with vaccination and infection. Results: 8809 infants met eligibility criteria, including 99 delta cases (4365 controls) and 1501 omicron cases (4847 controls). Infant vaccine effectiveness from two maternal doses was 95% (95% confidence interval 88% to 98%) against delta infection and 97% (73% to 100%) against infant hospital admission due to delta and 45% (37% to 53%) against omicron infection and 53% (39% to 64%) against hospital admission due to omicron. Vaccine effectiveness for three doses was 73% (61% to 80%) against omicron infection and 80% (64% to 89%) against hospital admission due to omicron. Vaccine effectiveness for two doses against infant omicron infection was highest with the second dose in the third trimester (53% (42% to 62%)) compared with the first (47% (31% to 59%)) or second (37% (24% to 47%)) trimesters. Vaccine effectiveness for two doses against infant omicron infection decreased from 57% (44% to 66%) between birth and eight weeks to 40% (21% to 54%) after 16 weeks of age. Conclusions: Maternal covid-19 vaccination with a second dose during pregnancy was highly effective against delta and moderately effective against omicron infection and hospital admission in infants during the first six months of life. A third vaccine dose bolstered protection against omicron. Effectiveness for two doses was highest with maternal vaccination in the third trimester, and effectiveness decreased in infants beyond eight weeks of age.en_US
dc.description.sponsorshipCanadian Institutes of Health Researchen_US
dc.language.isoenen_US
dc.publisherBMJen_US
dc.relation.urlhttps://www.bmj.com/content/380/bmj-2022-074035.longen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleMaternal mRNA covid-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants: test negative design studyen_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleBMJen_US
dc.source.beginpagee074035
dc.description.versionVoRen_US
refterms.dateFOA2024-06-17T18:17:44Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentEpidemiology and Biostatisticsen_US
dc.description.degreelevelN/Aen_US


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