Testing effects of glycocalyx inhibition by mannose on cell adhesion and mechanosensation of Dictyostelium discoideum.

Abstract

Social amoeba Dictyostelium discoideum is used as a model organism to understand the role of adhesion in directed molility guided by shear flow. This study will address whether inhibition of the cell’s sugar coating (glycocalyx) by competition with mannose affects its ability to adhere and sense mechanical cues.