Follicular Transplantation, Microneedling, and Adjuvant Narrow-band Ultraviolet-B Irradiation as Cost-Effective Regimens for Palmar-Plantar Vitiligo: A Pilot Study
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Author
Feily, AmirFiroozifard, Abdollah
Sokhandani, Toktam
Elosegui-Rodriguez, Perla
Perez-Rivera, Evian
Lange, Christopher S
Hosseinpoor, Masoomeh
Ramirez-Fort, Marigdalia K
Keyword
co2 fractional laserhair transplantation
melanocytic stem cells
micro needling
nbuvb
ultraviolet radiation (uvr) therapy
vitiligo
Journal title
CureusDate Published
2020-04-28
Metadata
Show full item recordAbstract
Treatment of refractory palmar-plantar vitiligo is particularly challenging because the skin in these regions has a limited supply of follicle-derived melanocytic stem cells. Autologous hair transplantation monotherapy is effective in some forms of vitiligo through the provision of melanocytic stem cells. CO2 laser followed by exposure to light (i.e., sunlight or narrow-band ultraviolet-B [nbUVB]) has independently shown to be an effective treatment strategy. Recently, it was found that the combination of hair transplantation and CO2 laser followed by nbUVB exposure had superior efficacy to either modality as monotherapy. Similar to CO2 laser, microneedling produces skin cell proliferation and releases pro-pigmentary cytokines. Given the important role of the cytokines in vitiliginous skin, microneedling may also be an effective therapeutic modality for refractory vitiligo. Herein, we conducted a pilot study to evaluate the efficacy of hair transplantation and CO2 laser or microneedling followed by nbUVB. Microneedling and fractional CO2 laser in combination with hair transplantation and nbUVB both demonstrated utility in the induction of repigmentation in refractory palmar-plantar vitiligo; however, a larger trial would be needed to determine a difference in treatment efficacy. Nonetheless, microneedling is cost-effective and requires minimal training; therefore, microneedling can be easily incorporated into standard dermatological practice.Citation
Feily A, Firoozifard A, Sokhandani T, Elosegui-Rodriguez P, Perez-Rivera E, Lange CS, Hosseinpoor M, Ramirez-Fort MK. Follicular Transplantation, Microneedling, and Adjuvant Narrow-band Ultraviolet-B Irradiation as Cost-Effective Regimens for Palmar-Plantar Vitiligo: A Pilot Study. Cureus. 2020 Apr 28;12(4):e7878. doi: 10.7759/cureus.7878. PMID: 32489732; PMCID: PMC7255558.DOI
10.7759/cureus.7878ae974a485f413a2113503eed53cd6c53
10.7759/cureus.7878
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