Clonogenic Inactivation of Colon Cancer-derived Cells Treated with 5-Fluorouracil and Indomethacin in Hybrid Spheroids
dc.contributor.author | Djordjevic, Bozidar | |
dc.contributor.author | Lange, Christopher S. | |
dc.contributor.author | Schwartz, Michael S. | |
dc.contributor.author | Rotman, Marvin | |
dc.date.accessioned | 2024-04-03T19:24:51Z | |
dc.date.available | 2024-04-03T19:24:51Z | |
dc.date.issued | 1998-07-08 | |
dc.identifier.citation | Djordjevic B, Lange CS, Schwartz MS, Rotman M. Clonogenic inactivation of colon cancer-derived cells treated with 5-fluorouracil and indomethacin in hybrid spheroids. Acta Oncol. 1998;37(7-8):735-9. doi: 10.1080/028418698430124. PMID: 10050995. | en_US |
dc.identifier.issn | 0284-186X | |
dc.identifier.eissn | 1651-226X | |
dc.identifier.doi | 10.1080/028418698430124 | |
dc.identifier.pmid | 10050995 | |
dc.identifier.pii | 10.1080/028418698430124 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12648/14770 | |
dc.description.abstract | The clonogenic hybrid spheroid assay has been used to determine the toxicity of 5-fluorouracil (5-FU), alone or in combination with indomethacin, in LoVo cells (a human colon adenocarcinoma line). The principal finding was that 5-FU toxicity, determined as loss of colony-forming ability, increased as a function of dose (concentration x duration of exposure), and that indomethacin causes a generalized alleviation of 5-FU toxicity, but only if given concurrently with 5-FU. The implications of these findings in the control of cancer cells by 5-FU are discussed. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MJS Publishing, Medical Journals Sweden AB | en_US |
dc.relation.url | https://www.tandfonline.com/doi/abs/10.1080/028418698430124 | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Radiology, Nuclear Medicine and imaging | en_US |
dc.subject | Oncology | en_US |
dc.subject | Hematology | en_US |
dc.subject | General Medicine | en_US |
dc.title | Clonogenic Inactivation of Colon Cancer-derived Cells Treated with 5-Fluorouracil and Indomethacin in Hybrid Spheroids | en_US |
dc.type | Article/Review | en_US |
dc.source.journaltitle | Acta Oncologica | en_US |
dc.source.volume | 37 | |
dc.source.issue | 7-8 | |
dc.source.beginpage | 735 | |
dc.source.endpage | 739 | |
dc.description.version | VoR | en_US |
refterms.dateFOA | 2024-04-03T19:24:52Z | |
dc.description.institution | SUNY Downstate | en_US |
dc.description.department | Radiation Oncology | en_US |
dc.description.degreelevel | N/A | en_US |
dc.identifier.issue | 7-8 | en_US |