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dc.contributor.authorDjordjevic, Bozidar
dc.contributor.authorLange, Christopher S.
dc.contributor.authorSchwartz, Michael S.
dc.contributor.authorRotman, Marvin
dc.date.accessioned2024-04-03T19:24:51Z
dc.date.available2024-04-03T19:24:51Z
dc.date.issued1998-07-08
dc.identifier.citationDjordjevic B, Lange CS, Schwartz MS, Rotman M. Clonogenic inactivation of colon cancer-derived cells treated with 5-fluorouracil and indomethacin in hybrid spheroids. Acta Oncol. 1998;37(7-8):735-9. doi: 10.1080/028418698430124. PMID: 10050995.en_US
dc.identifier.issn0284-186X
dc.identifier.eissn1651-226X
dc.identifier.doi10.1080/028418698430124
dc.identifier.pmid10050995
dc.identifier.pii10.1080/028418698430124
dc.identifier.urihttp://hdl.handle.net/20.500.12648/14770
dc.description.abstractThe clonogenic hybrid spheroid assay has been used to determine the toxicity of 5-fluorouracil (5-FU), alone or in combination with indomethacin, in LoVo cells (a human colon adenocarcinoma line). The principal finding was that 5-FU toxicity, determined as loss of colony-forming ability, increased as a function of dose (concentration x duration of exposure), and that indomethacin causes a generalized alleviation of 5-FU toxicity, but only if given concurrently with 5-FU. The implications of these findings in the control of cancer cells by 5-FU are discussed.en_US
dc.language.isoenen_US
dc.publisherMJS Publishing, Medical Journals Sweden ABen_US
dc.relation.urlhttps://www.tandfonline.com/doi/abs/10.1080/028418698430124en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRadiology, Nuclear Medicine and imagingen_US
dc.subjectOncologyen_US
dc.subjectHematologyen_US
dc.subjectGeneral Medicineen_US
dc.titleClonogenic Inactivation of Colon Cancer-derived Cells Treated with 5-Fluorouracil and Indomethacin in Hybrid Spheroidsen_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleActa Oncologicaen_US
dc.source.volume37
dc.source.issue7-8
dc.source.beginpage735
dc.source.endpage739
dc.description.versionVoRen_US
refterms.dateFOA2024-04-03T19:24:52Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentRadiation Oncologyen_US
dc.description.degreelevelN/Aen_US
dc.identifier.issue7-8en_US


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