Clonogenic Inactivation of Colon Cancer-derived Cells Treated with 5-Fluorouracil and Indomethacin in Hybrid Spheroids
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Journal title
Acta OncologicaDate Published
1998-07-08Publication Volume
37Publication Issue
7-8Publication Begin page
735Publication End page
739
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Show full item recordAbstract
The clonogenic hybrid spheroid assay has been used to determine the toxicity of 5-fluorouracil (5-FU), alone or in combination with indomethacin, in LoVo cells (a human colon adenocarcinoma line). The principal finding was that 5-FU toxicity, determined as loss of colony-forming ability, increased as a function of dose (concentration x duration of exposure), and that indomethacin causes a generalized alleviation of 5-FU toxicity, but only if given concurrently with 5-FU. The implications of these findings in the control of cancer cells by 5-FU are discussed.Citation
Djordjevic B, Lange CS, Schwartz MS, Rotman M. Clonogenic inactivation of colon cancer-derived cells treated with 5-fluorouracil and indomethacin in hybrid spheroids. Acta Oncol. 1998;37(7-8):735-9. doi: 10.1080/028418698430124. PMID: 10050995.DOI
10.1080/028418698430124ae974a485f413a2113503eed53cd6c53
10.1080/028418698430124
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