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HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype.

dc.contributor.authorSundermann, Erin E
dc.contributor.authorBishop, Jeffrey R
dc.contributor.authorRubin, Leah H
dc.contributor.authorAouizerat, Bradley
dc.contributor.authorWilson, Tracey E
dc.contributor.authorWeber, Kathleen M
dc.contributor.authorCohen, Mardge
dc.contributor.authorGolub, Elizabeth
dc.contributor.authorAnastos, Kathryn
dc.contributor.authorLiu, Chenglong
dc.contributor.authorCrystal, Howard
dc.contributor.authorPearce, Celeste L
dc.contributor.authorMaki, Pauline M
dc.date.accessioned2023-10-13T16:49:28Z
dc.date.available2023-10-13T16:49:28Z
dc.date.issued2013-07-17
dc.identifier.citationSundermann EE, Bishop JR, Rubin LH, Aouizerat B, Wilson TE, Weber KM, Cohen M, Golub E, Anastos K, Liu C, Crystal H, Pearce CL, Maki PM. HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype. AIDS. 2013 Jul 17;27(11):1779-82. doi: 10.1097/QAD.0b013e328361c6a1. PMID: 23807274; PMCID: PMC3897122.en_US
dc.identifier.eissn1473-5571
dc.identifier.doi10.1097/QAD.0b013e328361c6a1
dc.identifier.pmid23807274
dc.identifier.urihttp://hdl.handle.net/20.500.12648/13045
dc.description.abstractObjective: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women.
dc.description.abstractDesign: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women.
dc.description.abstractMethods: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS.
dc.description.abstractResults: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Z  =  -3.60, P  < 0.001.
dc.description.abstractConclusion: We report the novel finding of an association between the Val158Met genotype and HIV serostatus that may be mediated through the impact of dopamine function on propensity for risk-taking.
dc.language.isoenen_US
dc.relation.urlhttps://journals.lww.com/aidsonline/fulltext/2013/07170/hiv_serostatus_differs_by.11.aspxen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleHIV serostatus differs by catechol-O-methyltransferase Val158Met genotype.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAIDS (London, England)en_US
dc.source.volume27
dc.source.issue11
dc.source.beginpage1779
dc.source.endpage82
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland
dc.description.versionVoRen_US
refterms.dateFOA2023-10-13T16:49:29Z
html.description.abstractObjective: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women.
html.description.abstractDesign: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women.
html.description.abstractMethods: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS.
html.description.abstractResults: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Z  =  -3.60, P  < 0.001.
html.description.abstractConclusion: We report the novel finding of an association between the Val158Met genotype and HIV serostatus that may be mediated through the impact of dopamine function on propensity for risk-taking.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentCommunity Health Sciencesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalAIDS (London, England)
dc.identifier.issue11en_US


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