HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype.
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Author
Sundermann, Erin EBishop, Jeffrey R
Rubin, Leah H
Aouizerat, Bradley
Wilson, Tracey E
Weber, Kathleen M
Cohen, Mardge
Golub, Elizabeth
Anastos, Kathryn
Liu, Chenglong
Crystal, Howard
Pearce, Celeste L
Maki, Pauline M
Journal title
AIDS (London, England)Date Published
2013-07-17Publication Volume
27Publication Issue
11Publication Begin page
1779Publication End page
82
Metadata
Show full item recordAbstract
Objective: The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with increased cortical dopamine and risk behaviors including illicit drug use and unprotected sex. Therefore, we examined whether or not the distribution of the Val158Met genotype differed between HIV-infected and HIV-uninfected women.Design: Cross-sectional analysis using data from the Women's Interagency HIV Study (WIHS), the largest longitudinal cohort study of HIV in women.
Methods: We conducted an Armitage-Cochran test and logistic regression to compare genotype frequencies between 1848 HIV-infected and 612 HIV-uninfected women in WIHS.
Results: The likelihood of carrying one or two Met alleles was greater in HIV-infected women (61%) compared to HIV-uninfected women (54%), Z = -3.60, P < 0.001.
Conclusion: We report the novel finding of an association between the Val158Met genotype and HIV serostatus that may be mediated through the impact of dopamine function on propensity for risk-taking.
Citation
Sundermann EE, Bishop JR, Rubin LH, Aouizerat B, Wilson TE, Weber KM, Cohen M, Golub E, Anastos K, Liu C, Crystal H, Pearce CL, Maki PM. HIV serostatus differs by catechol-O-methyltransferase Val158Met genotype. AIDS. 2013 Jul 17;27(11):1779-82. doi: 10.1097/QAD.0b013e328361c6a1. PMID: 23807274; PMCID: PMC3897122.DOI
10.1097/QAD.0b013e328361c6a1ae974a485f413a2113503eed53cd6c53
10.1097/QAD.0b013e328361c6a1
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