Increase in single-tablet regimen use and associated improvements in adherence-related outcomes in HIV-infected women.
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AuthorHanna, David B
Hessol, Nancy A
Golub, Elizabeth T
Cocohoba, Jennifer M
Cohen, Mardge H
Levine, Alexandra M
Wilson, Tracey E
Kaplan, Robert C
Journal titleJournal of acquired immune deficiency syndromes (1999)
Publication Begin page587
Publication End page96
MetadataShow full item record
AbstractIntroduction: The use of single-tablet antiretroviral therapy (ART) regimens and its implications on adherence among HIV-infected women have not been well described.
Methods: Participants were enrolled in the Women's Interagency HIV Study, a longitudinal study of HIV infection in US women. We examined semiannual trends in single-tablet regimen use and ART adherence, defined as self-reported 95% adherence in the past 6 months, during 2006-2013. In a nested cohort study, we assessed the comparative effectiveness of a single-tablet versus a multiple-tablet regimen with respect to adherence, virologic suppression, quality of life, and AIDS-defining events, using propensity score matching to account for demographic, behavioral, and clinical confounders. We also examined these outcomes in a subset of women switching from a multiple- to single-tablet regimen using a case-crossover design.
Results: We included 15,523 person-visits, representing 1727 women (53% black, 29% Hispanic, 25% IDU, median age 47). Use of single-tablet regimens among ART users increased from 7% in 2006% to 27% in 2013; adherence increased from 78% to 85% during the same period (both P < 0.001). Single-tablet regimen use was significantly associated with increased adherence (adjusted risk ratio: 1.05; 95% confidence interval: 1.03 to 1.08) and virologic suppression (risk ratio: 1.06; 95% confidence interval: 1.01 to 1.11), while associations with improved quality of life and fewer AIDS-defining events did not achieve statistical significance. Similar findings were observed among the subset of switchers.
Conclusions: Single-tablet regimen use was associated with increased adherence and virologic suppression. Despite this, 15% of women prescribed ART were still not optimally adherent; additional interventions are needed to maximize therapeutic benefits.
CitationHanna DB, Hessol NA, Golub ET, Cocohoba JM, Cohen MH, Levine AM, Wilson TE, Young M, Anastos K, Kaplan RC. Increase in single-tablet regimen use and associated improvements in adherence-related outcomes in HIV-infected women. J Acquir Immune Defic Syndr. 2014 Apr 15;65(5):587-96. doi: 10.1097/QAI.0000000000000082. PMID: 24326606; PMCID: PMC3999284.
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