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dc.contributor.authorElbur, Abubaker Ibrahim
dc.contributor.authorGhebremichael, Musie
dc.contributor.authorKonkle-Parker, Deborah
dc.contributor.authorJones, Deborah L
dc.contributor.authorCollins, Shelby
dc.contributor.authorAdimora, Adaora A.
dc.contributor.authorSchneider, Michael F.
dc.contributor.authorCohen, Mardge H.
dc.contributor.authorTamraz, Bani
dc.contributor.authorPlankey, Michael
dc.contributor.authorWilson, Tracey
dc.contributor.authorAdedimeji, Adebola
dc.contributor.authorHaberer, Jessica E.
dc.contributor.authorJacobson, Denise L.
dc.date.accessioned2023-07-12T18:20:11Z
dc.date.available2023-07-12T18:20:11Z
dc.date.issued2023-05-13
dc.identifier.citationElbur AI, Ghebremichael M, Konkle-Parker D, Jones DL, Collins S, Adimora AA, Schneider MF, Cohen MH, Tamraz B, Plankey M, Wilson T, Adedimeji A, Haberer JE, Jacobson DL. Dual trajectories of antiretroviral therapy adherence and polypharmacy in women with HIV in the United States. AIDS Res Ther. 2023 May 13;20(1):29. doi: 10.1186/s12981-023-00520-4. PMID: 37179294; PMCID: PMC10182649.en_US
dc.identifier.eissn1742-6405
dc.identifier.doi10.1186/s12981-023-00520-4
dc.identifier.pii520
dc.identifier.urihttp://hdl.handle.net/20.500.12648/10450
dc.description.abstractBackground: Polypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy. Methods: We included women with HIV (aged ≥ 18) enrolled in the Women's Interagency HIV Study in the United States from 2014 to 2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy. Results: Overall, 1,538 were eligible (median age of 49 years). GBTM analysis revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory. GBTM identified four polypharmacy trajectories with 45% categorized in the consistently low group. Conclusions: The joint model did not reveal any interrelationship between ART adherence and polypharmacy trajectories. Future research should consider examining the interrelationship between both variables using objective measures of adherence.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.urlhttps://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-023-00520-4en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectPharmacology (medical)en_US
dc.subjectVirologyen_US
dc.subjectMolecular Medicineen_US
dc.titleDual trajectories of antiretroviral therapy adherence and polypharmacy in women with HIV in the United Statesen_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAIDS Research and Therapyen_US
dc.source.volume20
dc.source.issue1
dc.description.versionVoRen_US
refterms.dateFOA2023-07-12T18:20:13Z
dc.description.institutionSUNY Downstateen_US
dc.description.departmentInfectious Diseasesen_US
dc.description.degreelevelN/Aen_US
dc.identifier.issue1en_US


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