Cost-effectiveness analysis of Chlamydia trachomatis screening in Dutch pregnant women.
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AuthorRours, G I J G
Smith-Norowitz, Tamar Anne
Hammerschlag, Margaret R
Verkooyen, R P
de Groot, R
Verbrugh, H A
Postma, M J
Keyword1. Screening pregnant women for C. trachomatis is cost saving for the Netherlands
2. Chlamydia screening is even more cost saving when aiming at women <30 years or with first pregnancies
3. This is the first CEA of antenatal C. trachomatis screening that includes preterm delivery
Journal titlePathogens and global health
Publication Begin page292
Publication End page302
MetadataShow full item record
AbstractChlamydia trachomatis infections during pregnancy may have serious consequences for women and their offspring. Chlamydial infections are largely asymptomatic. Hence, prevention is based on screening. The objective of this study was to estimate the cost-effectiveness of C. trachomatis screening during pregnancy. We used a health-economic decision analysis model, which included potential health outcomes of C. trachomatis infection for women, partners and infants, and premature delivery. We estimated the cost-effectiveness from a societal perspective using recent prevalence data from a population-based prospective cohort study among pregnant women in the Netherlands. We calculated the averted costs by linking health outcomes with health care costs and productivity losses. Cost-effectiveness was expressed as net costs per major outcome prevented and was estimated in base-case analysis, sensitivity, and scenario analysis. In the base-case analysis, the costs to detect 1000 pregnant women with C. trachomatis were estimated at €527,900. Prevention of adverse health outcomes averted €626,800 in medical costs, resulting in net cost savings. Sensitivity analysis showed that net cost savings remained with test costs up to €22 (test price €19) for a broad range of variation in underlying assumptions. Scenario analysis showed even more cost savings with targeted screening for women less than 30 years of age or with first pregnancies only. Antenatal screening for C. trachomatis is a cost-saving intervention when testing all pregnant women in the Netherlands. Savings increase even further when testing women younger than 30 years of age or with pregnancies only.
CitationRours GI, Smith-Norowitz TA, Ditkowsky J, Hammerschlag MR, Verkooyen RP, de Groot R, Verbrugh HA, Postma MJ. Cost-effectiveness analysis of Chlamydia trachomatis screening in Dutch pregnant women. Pathog Glob Health. 2016 Oct-Dec;110(7-8):292-302. doi: 10.1080/20477724.2016.1258162. PMID: 27958189; PMCID: PMC5189868.
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- Issue date: 2001 May-Jun
- Cost-benefit analysis of Chlamydia trachomatis screening in pregnant women in a high burden setting in the United States.
- Authors: Ditkowsky J, Shah KH, Hammerschlag MR, Kohlhoff S, Smith-Norowitz TA
- Issue date: 2017 Feb 18
- Systematic screening for Chlamydia trachomatis: estimating cost-effectiveness using dynamic modeling and Dutch data.
- Authors: de Vries R, van Bergen JE, de Jong-van den Berg LT, Postma MJ, PILOT-CT Study Group
- Issue date: 2006 Jan-Feb
- [Screening for asymptomatic Chlamydia trachomatis infection in pregnancy; cost-effectiveness favorable at a minimum prevalence rate of 3% or more].
- Authors: Postma MJ, Bakker A, Welte R, van Bergen JE, van den Hoek JA, de Jong-van den Berg LT, Jager JC
- Issue date: 2000 Dec 2
- [Opportunistic screening for genital infections with Chlamydia trachomatis in sexually active population of Amsterdam. II. Cost-effectiveness analysis of screening women].
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- Issue date: 1999 Mar 27
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