In vitro activity of nemonoxacin, a novel nonfluorinated quinolone antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae.

Chotikanatis, Kobkul; Kohlhoff, Stephan A; Hammerschlag, Margaret R

dc.contributor.author	Chotikanatis, Kobkul
dc.contributor.author	Kohlhoff, Stephan A
dc.contributor.author	Hammerschlag, Margaret R
dc.date.accessioned	2023-07-05T18:41:28Z
dc.date.available	2023-07-05T18:41:28Z
dc.date.issued	2014-12
dc.identifier.citation	Chotikanatis K, Kohlhoff SA, Hammerschlag MR. In vitro activity of nemonoxacin, a novel nonfluorinated quinolone antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae. Antimicrob Agents Chemother. 2014;58(3):1800-1. doi: 10.1128/AAC.02263-13. Epub 2013 Dec 23. PMID: 24366753; PMCID: PMC3957896.	en_US
dc.identifier.eissn	1098-6596
dc.identifier.doi	10.1128/AAC.02263-13
dc.identifier.pmid	24366753
dc.identifier.uri	http://hdl.handle.net/20.500.12648/10389
dc.description.abstract	The in vitro activities of nemonoxacin, levofloxacin, azithromycin, and doxycycline were tested against 10 isolates each of Chlamydia trachomatis and Chlamydia pneumoniae. The MICs at which 90% of the isolates of both C. trachomatis and C. pneumoniae were inhibited (MIC90s) were 0.06 μg/ml (range, 0.03 to 0.13 μg/ml). The minimal bactericidal concentrations at which 90% of the isolates were killed by nemonoxacin (MBC90s) were 0.06 μg/ml for C. trachomatis (range, 0.03 to 0.125 μg/ml) and 0.25 for C. pneumoniae (range, 0.015 to 0.5 μg/ml).
dc.language.iso	en	en_US
dc.relation.url	https://journals.asm.org/doi/epub/10.1128/aac.02263-13	en_US
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.title	In vitro activity of nemonoxacin, a novel nonfluorinated quinolone antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae.	en_US
dc.type	Article/Review	en_US
dc.source.journaltitle	Antimicrobial agents and chemotherapy	en_US
dc.source.volume	58
dc.source.issue	3
dc.source.beginpage	1800
dc.source.endpage	1
dc.source.country	United States
dc.description.version	VoR	en_US
refterms.dateFOA	2023-07-05T18:41:29Z
html.description.abstract	The in vitro activities of nemonoxacin, levofloxacin, azithromycin, and doxycycline were tested against 10 isolates each of Chlamydia trachomatis and Chlamydia pneumoniae. The MICs at which 90% of the isolates of both C. trachomatis and C. pneumoniae were inhibited (MIC90s) were 0.06 μg/ml (range, 0.03 to 0.13 μg/ml). The minimal bactericidal concentrations at which 90% of the isolates were killed by nemonoxacin (MBC90s) were 0.06 μg/ml for C. trachomatis (range, 0.03 to 0.125 μg/ml) and 0.25 for C. pneumoniae (range, 0.015 to 0.5 μg/ml).
dc.description.institution	SUNY Downstate	en_US
dc.description.department	Pediatrics	en_US
dc.description.degreelevel	N/A	en_US
dc.identifier.journal	Antimicrobial agents and chemotherapy
dc.identifier.issue	3	en_US