In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae.

Roblin, Patricia M; Kohlhoff, Stephan A; Parker, Charles; Hammerschlag, Margaret R

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Author

Roblin, Patricia M
Kohlhoff, Stephan A
Parker, Charles
Hammerschlag, Margaret R

Journal title

Antimicrobial agents and chemotherapy

Date Published

2010-03

Publication Volume

Publication Issue

Publication Begin page

1358

Publication End page

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URI

http://hdl.handle.net/20.500.12648/10378

Abstract

The in vitro activities of CEM-101, telithromycin, azithromycin, clarithromycin, and doxycycline against 10 isolates each of Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae were tested. The MIC at which 90% of the isolates of both C. trachomatis and C. pneumoniae were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by CEM-101 were 0.25 microg/ml (ranges, 0.125 to 0.5 microg/ml for C. trachomatis and 0.25 to 1.0 microg/ml for C. pneumoniae).

Citation

Roblin PM, Kohlhoff SA, Parker C, Hammerschlag MR. In vitro activity of CEM-101, a new fluoroketolide antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae. Antimicrob Agents Chemother. 2010 Mar;54(3):1358-9. doi: 10.1128/AAC.01343-09. Epub 2009 Dec 28. PMID: 20038627; PMCID: PMC2825974.

DOI

10.1128/AAC.01343-09

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Downstate College of Medicine

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