Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae.

Riska, Paul F; Kutlin, Andrei; Ajiboye, Patrick; Cua, Arnold; Roblin, Patricia M; Hammerschlag, Margaret R

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Author

Riska, Paul F
Kutlin, Andrei
Ajiboye, Patrick
Cua, Arnold
Roblin, Patricia M
Hammerschlag, Margaret R

Journal title

Antimicrobial agents and chemotherapy

Date Published

2004-09

Publication Volume

Publication Issue

Publication Begin page

3586

Publication End page

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URI

http://hdl.handle.net/20.500.12648/10368

Abstract

Three clinical Chlamydia pneumoniae isolates for which the MIC of azithromycin increased after treatment were investigated for genetic evidence of macrolide resistance. Attempts to induce antibiotic resistance in vitro were made. No genetic mechanism was identified for the phenotypic change in these C. pneumoniae isolates. No macrolide resistance was obtained in vitro.

Citation

Riska PF, Kutlin A, Ajiboye P, Cua A, Roblin PM, Hammerschlag MR. Genetic and culture-based approaches for detecting macrolide resistance in Chlamydia pneumoniae. Antimicrob Agents Chemother. 2004 Sep;48(9):3586-90. doi: 10.1128/AAC.48.9.3586-3590.2004. PMID: 15328134; PMCID: PMC514725.

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Downstate College of Medicine

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