In vitro activity of a novel diaminopyrimidine compound, iclaprim, against Chlamydia trachomatis and C. pneumoniae.

Kohlhoff, S A; Roblin, P M; Reznik, T; Hawser, S; Islam, K; Hammerschlag, M R

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Author

Kohlhoff, S A
Roblin, P M
Reznik, T
Hawser, S
Islam, K
Hammerschlag, M R

Journal title

Antimicrobial agents and chemotherapy

Date Published

2004-05

Publication Volume

Publication Issue

Publication Begin page

1885

Publication End page

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URI

http://hdl.handle.net/20.500.12648/10367

Abstract

The in vitro activities of iclaprim, a novel dihydrofolate reductase inhibitor, azithromycin, and levofloxacin were tested against 10 strains of Chlamydia trachomatis and 10 isolates of Chlamydia pneumoniae. For C. trachomatis and C. pneumoniae, the iclaprim MIC and minimal bactericidal concentration at which 90% of isolates were inhibited (MIC(90) and MBC(90)) were 0.5 micro g/ml, compared to an azithromycin MIC(90) and MBC(90) of 0.125 micro g/ml and levofloxacin MIC(90)s and MBC(90)s of 1 micro g/ml for C. trachomatis and 0.5 micro g/ml for C. pneumoniae.

Citation

Kohlhoff SA, Roblin PM, Reznik T, Hawser S, Islam K, Hammerschlag MR. In vitro activity of a novel diaminopyrimidine compound, iclaprim, against Chlamydia trachomatis and C. pneumoniae. Antimicrob Agents Chemother. 2004 May;48(5):1885-6. doi: 10.1128/AAC.48.5.1885-1886.2004. PMID: 15105151; PMCID: PMC400585.

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Downstate College of Medicine

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