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In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae.

dc.contributor.authorRoblin, Patricia M
dc.contributor.authorHammerschlag, Margaret R
dc.date.accessioned2023-07-05T16:03:19Z
dc.date.available2023-07-05T16:03:19Z
dc.date.issued2003-04
dc.identifier.citationRoblin PM, Hammerschlag MR. In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae. Antimicrob Agents Chemother. 2003 Apr;47(4):1447-8. doi: 10.1128/AAC.47.4.1447-1448.2003. PMID: 12654690; PMCID: PMC152502.en_US
dc.identifier.issn0066-4804
dc.identifier.pmid12654690
dc.identifier.urihttp://hdl.handle.net/20.500.12648/10366
dc.description.abstractThe in vitro activity of NVP-PDF386 (VRC4887), a novel new peptide deformylase inhibitor, and those of levofloxacin and clarithromycin were tested against 21 isolates of Chlamydia pneumoniae. The MIC at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by NVP-PDF386 for all isolates of C. pneumoniae were 0.008 micro g/ml (range, 0.008 to 0.015 micro g/ml) compared to 0.25 and 0.06 micro g/ml for levofloxacin and clarithromycin, respectively.
dc.language.isoenen_US
dc.relation.urlhttps://journals.asm.org/doi/epub/10.1128/aac.47.4.1447-1448.2003en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleIn vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleAntimicrobial agents and chemotherapyen_US
dc.source.volume47
dc.source.issue4
dc.source.beginpage1447
dc.source.endpage8
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2023-07-05T16:03:20Z
html.description.abstractThe in vitro activity of NVP-PDF386 (VRC4887), a novel new peptide deformylase inhibitor, and those of levofloxacin and clarithromycin were tested against 21 isolates of Chlamydia pneumoniae. The MIC at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by NVP-PDF386 for all isolates of C. pneumoniae were 0.008 micro g/ml (range, 0.008 to 0.015 micro g/ml) compared to 0.25 and 0.06 micro g/ml for levofloxacin and clarithromycin, respectively.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPediatricsen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalAntimicrobial agents and chemotherapy
dc.identifier.issue4en_US


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