In vitro activities of BMS-284756 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae.

Malay, Sheila; Roblin, Patricia M; Reznik, Tamara; Kutlin, Andrei; Hammerschlag, Margaret R

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Author

Malay, Sheila
Roblin, Patricia M
Reznik, Tamara
Kutlin, Andrei
Hammerschlag, Margaret R

Journal title

Antimicrobial agents and chemotherapy

Date Published

2002-02

Publication Volume

Publication Issue

Publication Begin page

517

Publication End page

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URI

http://hdl.handle.net/20.500.12648/10363

Abstract

The in vitro activities of BMS-284756 (a novel des-fluoroquinolone), levofloxacin, moxifloxacin, and clarithromycin were tested against 5 strains of Chlamydia trachomatis and 20 isolates of Chlamydia pneumoniae. The MIC at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by BMS-284756 for all isolates of C. pneumoniae and C. trachomatis was 0.015 microg/ml (range, 0.015 to 0.03 microg/ml). BMS-284756 was the most active quinolone tested.

Citation

Malay S, Roblin PM, Reznik T, Kutlin A, Hammerschlag MR. In vitro activities of BMS-284756 against Chlamydia trachomatis and recent clinical isolates of Chlamydia pneumoniae. Antimicrob Agents Chemother. 2002 Feb;46(2):517-8. doi: 10.1128/AAC.46.2.517-518.2002. PMID: 11796366; PMCID: PMC127069.

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Downstate College of Medicine

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