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Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?

dc.contributor.authorHammerschlag, M R
dc.contributor.authorKe, Z
dc.contributor.authorLu, F
dc.contributor.authorRoblin, P
dc.contributor.authorBoman, J
dc.contributor.authorKalman, B
dc.date.accessioned2023-06-30T17:13:24Z
dc.date.available2023-06-30T17:13:24Z
dc.date.issued2000-11
dc.identifier.citationHammerschlag MR, Ke Z, Lu F, Roblin P, Boman J, Kalman B. Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis? J Clin Microbiol. 2000 Nov;38(11):4274-6. doi: 10.1128/JCM.38.11.4274-4276.2000. PMID: 11060110; PMCID: PMC87583.en_US
dc.identifier.issn0095-1137
dc.identifier.pmid11060110
dc.identifier.urihttp://hdl.handle.net/20.500.12648/10353
dc.description.abstractWe investigated the presence of Chlamydia pneumoniae in 81 normal and pathological specimens obtained from postmortem brain tissues of patients with multiple sclerosis and with other neurological or nonneurological diseases. The assays used included PCR amplification of all DNA samples in the initial study. Culture and a second PCR amplification of the organism in a subset of 19 brain specimens were also performed in two separate laboratories. All results were negative. Thus, this study on a large number of brain tissues suggests that C. pneumoniae is not involved in inflammatory demyelination.
dc.language.isoenen_US
dc.relation.urlhttps://journals.asm.org/doi/epub/10.1128/jcm.38.11.4274-4276.2000en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleIs Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleJournal of clinical microbiologyen_US
dc.source.volume38
dc.source.issue11
dc.source.beginpage4274
dc.source.endpage6
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2023-06-30T17:13:25Z
html.description.abstractWe investigated the presence of Chlamydia pneumoniae in 81 normal and pathological specimens obtained from postmortem brain tissues of patients with multiple sclerosis and with other neurological or nonneurological diseases. The assays used included PCR amplification of all DNA samples in the initial study. Culture and a second PCR amplification of the organism in a subset of 19 brain specimens were also performed in two separate laboratories. All results were negative. Thus, this study on a large number of brain tissues suggests that C. pneumoniae is not involved in inflammatory demyelination.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPediatricsen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalJournal of clinical microbiology
dc.identifier.issue11en_US


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