Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis?
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Journal title
Journal of clinical microbiologyDate Published
2000-11Publication Volume
38Publication Issue
11Publication Begin page
4274Publication End page
6
Metadata
Show full item recordAbstract
We investigated the presence of Chlamydia pneumoniae in 81 normal and pathological specimens obtained from postmortem brain tissues of patients with multiple sclerosis and with other neurological or nonneurological diseases. The assays used included PCR amplification of all DNA samples in the initial study. Culture and a second PCR amplification of the organism in a subset of 19 brain specimens were also performed in two separate laboratories. All results were negative. Thus, this study on a large number of brain tissues suggests that C. pneumoniae is not involved in inflammatory demyelination.Citation
Hammerschlag MR, Ke Z, Lu F, Roblin P, Boman J, Kalman B. Is Chlamydia pneumoniae present in brain lesions of patients with multiple sclerosis? J Clin Microbiol. 2000 Nov;38(11):4274-6. doi: 10.1128/JCM.38.11.4274-4276.2000. PMID: 11060110; PMCID: PMC87583.Collections
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