In vitro activity of a new 8-methoxyquinolone, BAY 12-8039, against Chlamydia pneumoniae.

Roblin, P M; Hammerschlag, M R

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Author

Roblin, P M
Hammerschlag, M R

Journal title

Antimicrobial agents and chemotherapy

Date Published

1998-04

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Publication Issue

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951

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URI

http://hdl.handle.net/20.500.12648/10345

Abstract

The in vitro susceptibilities of 10 strains of Chlamydia pneumoniae to a new 8-methoxyquinolone, BAY 12-8039, and to ofloxacin, doxycycline, and erythromycin were determined. The activity of BAY 12-8039 was similar to that of ofloxacin, with a MIC at which 90% of the isolates had no inclusions and a minimal chlamydicidal concentration at which 90% of the isolates had no inclusions after passage of 1.0 microg/ml, but this activity was less than those of doxycycline and erythromycin.

Citation

Roblin PM, Hammerschlag MR. In vitro activity of a new 8-methoxyquinolone, BAY 12-8039, against Chlamydia pneumoniae. Antimicrob Agents Chemother. 1998 Apr;42(4):951-2. doi: 10.1128/AAC.42.4.951. PMID: 9559818; PMCID: PMC105577.

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Downstate College of Medicine

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