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dc.contributor.authorNakajo, M N
dc.contributor.authorRoblin, P M
dc.contributor.authorHammerschlag, M R
dc.contributor.authorSmith, P
dc.contributor.authorNowakowski, M
dc.date.accessioned2023-06-26T17:16:44Z
dc.date.available2023-06-26T17:16:44Z
dc.date.issued1990-11
dc.identifier.citationNakajo MN, Roblin PM, Hammerschlag MR, Smith P, Nowakowski M. Chlamydicidal activity of human alveolar macrophages. Infect Immun. 1990 Nov;58(11):3640-4. doi: 10.1128/iai.58.11.3640-3644.1990. PMID: 2228235; PMCID: PMC313709.en_US
dc.identifier.issn0019-9567
dc.identifier.pmid2228235
dc.identifier.urihttp://hdl.handle.net/20.500.12648/10319
dc.description.abstractPneumonia due to Chlamydia trachomatis is a disease limited mainly to infants under 6 months of age. Rare cases have been reported in immunocompromised adults. One possible reason for the propensity of the pneumonia to occur in the very young may be related to differences in the phagocytic and bactericidal capacity of alveolar macrophages (AMs) in young infants and adults. At birth a function of AMs is clearance of surfactant-related material from the alveolar surface. Studies in animals have suggested that engorgement of AMs with surfactant-related lipids may reduce the microbicidal capacity of these cells. In the present study we determined that AMs obtained from healthy, nonsmoking adults were capable of killing both human biovars of C. trachomatis, with complete killing observed by 48 h after inoculation. Preincubation of AMs from adults with surfactant did not reduce the capacity of the cells to kill C. trachomatis.
dc.language.isoenen_US
dc.relation.urlhttps://journals.asm.org/doi/10.1128/iai.58.11.3640-3644.1990en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleChlamydicidal activity of human alveolar macrophages.en_US
dc.typeArticle/Reviewen_US
dc.source.journaltitleInfection and immunityen_US
dc.source.volume58
dc.source.issue11
dc.source.beginpage3640
dc.source.endpage4
dc.source.countryUnited States
dc.description.versionVoRen_US
refterms.dateFOA2023-06-26T17:16:44Z
html.description.abstractPneumonia due to Chlamydia trachomatis is a disease limited mainly to infants under 6 months of age. Rare cases have been reported in immunocompromised adults. One possible reason for the propensity of the pneumonia to occur in the very young may be related to differences in the phagocytic and bactericidal capacity of alveolar macrophages (AMs) in young infants and adults. At birth a function of AMs is clearance of surfactant-related material from the alveolar surface. Studies in animals have suggested that engorgement of AMs with surfactant-related lipids may reduce the microbicidal capacity of these cells. In the present study we determined that AMs obtained from healthy, nonsmoking adults were capable of killing both human biovars of C. trachomatis, with complete killing observed by 48 h after inoculation. Preincubation of AMs from adults with surfactant did not reduce the capacity of the cells to kill C. trachomatis.
dc.description.institutionSUNY Downstateen_US
dc.description.departmentPediatricsen_US
dc.description.degreelevelN/Aen_US
dc.identifier.journalInfection and immunity


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