Loading...
Comorbidity of ADHD and adult bipolar disorder: A systematic review and meta-analysis
Schiweck, Carmen Arteaga-Henriquez, Gara Aichholzer, Mareike Edwin Thanarajah, Sharmili Vargas-Cáceres, Sebastian Matura, Silke Grimm, Oliver Haavik, Jan Kittel-Schneider, Sarah Ramos-Quiroga, Josep Antoni
Schiweck, Carmen
Arteaga-Henriquez, Gara
Aichholzer, Mareike
Edwin Thanarajah, Sharmili
Vargas-Cáceres, Sebastian
Matura, Silke
Grimm, Oliver
Haavik, Jan
Kittel-Schneider, Sarah
Ramos-Quiroga, Josep Antoni
Citations
Altmetric:
Journal Title
Neuroscience & Biobehavioral Reviews
Readers/Advisors
Journal Title
Term and Year
Publication Date
2021-05
Type
Book Title
Publication Volume
124
Publication Issue
Publication Begin
100
Publication End
123
Number of pages
Request File
Research Projects
Organizational Units
Journal Issue
Abstract
Attention-deficit / hyperactivity disorder (ADHD) and Bipolar Disorder (BD) are common mental disorders with a high degree of comorbidity. However, no systematic review with meta-analysis has aimed to quantify the degree of comorbidity between both disorders. To this end we performed a systematic search of the literature in October 2020. In a meta-analysis of 71 studies with 646,766 participants from 18 countries, it was found that about one in thirteen adults with ADHD was also diagnosed with BD (7.95 %; 95 % CI: 5.31-11.06), and nearly one in six adults with BD had ADHD (17.11 %; 95 % CI: 13.05-21.59 %). Substantial heterogeneity of comorbidity rates was present, highlighting the importance of contextual factors: Heterogeneity could partially be explained by diagnostic system, sample size and geographical location. Age of BD onset occurred earlier in patients with comorbid ADHD (3.96 years; 95 % CI: 2.65-5.26, p < 0.001). Cultural and methodological differences deserve attention for evaluating diagnostic criteria and clinicians should be aware of the high comorbidity rates to prevent misdiagnosis and provide optimal care for both disorders.