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The association of clinical follow-up intervals in HIV-infected persons with viral suppression on subsequent viral suppression.
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AIDS patient care and STDs
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2013-07-26
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27
Publication Issue
8
Publication Begin
459
Publication End
66
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apc.2013.0105.pdf
Adobe PDF, 144.47 KB
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Abstract
The recommendation for the frequency for routine clinical monitoring of persons with well-controlled HIV infection is based on evidence that relies on observed rather than intended follow-up intervals. We sought to determine if the scheduled follow-up interval is associated with subsequent virologic failure. Participants in this 6-clinic retrospective cohort study had an index clinic visit in 2008 and HIV viral load (VL) ≤400 c/mL. Univariate and multivariate tests evaluated if scheduling the next follow-up appointment at 3, 4, or 6 months predicted VL >400 c/mL at 12 months (VF). Among 2171 participants, 66%, 26%, and 8% were scheduled next follow-up visits at 3, 4, and 6 months, respectively. With missing 12-month VL considered VF, 25%, 25%, and 24% of persons scheduled at 3, 4, and 6 months had VF, respectively (p=0.95). Excluding persons with missing 12-month VL, 7.1%, 5.7%, and 4.5% had VF, respectively (p=0.35). Multivariable models yielded nonsignificant odds of VF by scheduled follow-up interval both when missing 12-month VL were considered VF and when persons with missing 12-month VL were excluded. We conclude that clinicians are able to make safe decisions extending follow-up intervals in persons with viral suppression, at least in the short-term.
Citation
Buscher A, Mugavero M, Westfall AO, Keruly J, Moore R, Drainoni ML, Sullivan M, Wilson TE, Rodriguez A, Metsch L, Gardner L, Marks G, Malitz F, Giordano TP. The association of clinical follow-up intervals in HIV-infected persons with viral suppression on subsequent viral suppression. AIDS Patient Care STDS. 2013 Aug;27(8):459-66. doi: 10.1089/apc.2013.0105. Epub 2013 Jul 26. PMID: 23886048; PMCID: PMC3739946.