Loading...
Chlamydicidal activity of human alveolar macrophages.
Journal Title
Infection and immunity
Keywords
Readers/Advisors
Journal Title
Term and Year
Publication Date
1990-11
Book Title
Publication Volume
58
Publication Issue
11
Publication Begin
3640
Publication End
4
Number of pages
Collections
Files
Loading...
iai00059-0184.pdf
Adobe PDF, 1.87 MB
Research Projects
Organizational Units
Journal Issue
Abstract
Pneumonia due to Chlamydia trachomatis is a disease limited mainly to infants under 6 months of age. Rare cases have been reported in immunocompromised adults. One possible reason for the propensity of the pneumonia to occur in the very young may be related to differences in the phagocytic and bactericidal capacity of alveolar macrophages (AMs) in young infants and adults. At birth a function of AMs is clearance of surfactant-related material from the alveolar surface. Studies in animals have suggested that engorgement of AMs with surfactant-related lipids may reduce the microbicidal capacity of these cells. In the present study we determined that AMs obtained from healthy, nonsmoking adults were capable of killing both human biovars of C. trachomatis, with complete killing observed by 48 h after inoculation. Preincubation of AMs from adults with surfactant did not reduce the capacity of the cells to kill C. trachomatis.
Citation
Nakajo MN, Roblin PM, Hammerschlag MR, Smith P, Nowakowski M. Chlamydicidal activity of human alveolar macrophages. Infect Immun. 1990 Nov;58(11):3640-4. doi: 10.1128/iai.58.11.3640-3644.1990. PMID: 2228235; PMCID: PMC313709.