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In vitro activity of a new ketolide antibiotic, HMR 3647, against Chlamydia pneumoniae.
Journal Title
Antimicrobial agents and chemotherapy
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1998-06
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Publication Volume
42
Publication Issue
6
Publication Begin
1515
Publication End
6
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aac.42.6.1515.pdf
Adobe PDF, 104.05 KB
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Abstract
The in vitro activities of HMR 3647, roxithromycin, erythromycin, and azithromycin against 19 strains of Chlamydia pneumoniae were tested. The MIC at which 90% of the isolates are inhibited and the minimum bactericidal concentration at which 90% of the isolates are killed of HMR 3647 were 0.25 microgram/ml (range, 0.015 to 2 micrograms/ml). Nine recently obtained clinical isolates from children with pneumonia were more susceptible (MICs, 0.015 to 0.0625 microgram/ml) than older strains that had been passaged more extensively.
Citation
Roblin PM, Hammerschlag MR. In vitro activity of a new ketolide antibiotic, HMR 3647, against Chlamydia pneumoniae. Antimicrob Agents Chemother. 1998 Jun;42(6):1515-6. doi: 10.1128/AAC.42.6.1515. PMID: 9624507; PMCID: PMC105635.