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Computer modeling for pharmacological treatments for dystonia.
Neymotin, Samuel A Dura-Bernal, Salvador
Moreno, Herman Lytton, William W
Neymotin, Samuel A
Moreno, Herman
Lytton, William W
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Drug discovery today. Disease models
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2017-03-31
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19
Publication Issue
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51
Publication End
57
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nihms858924.pdf
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Abstract
Dystonia is a movement disorder that produces involuntary muscle contractions. Current pharmacological treatments are of limited efficacy. Dystonia, like epilepsy is a disorder involving excessive activty of motor areas including motor cortex and several causal gene mutations have been identified. In order to evaluate potential novel agents for multitarget therapy for dystonia, we have developed a computer model of cortex that includes some of the complex array of molecular interactions that, along with membrane ion channels, control cell excitability.
Citation
Neymotin SA, Dura-Bernal S, Moreno H, Lytton WW. Computer modeling for pharmacological treatments for dystonia. Drug Discov Today Dis Models. 2016 Spring;19:51-57. doi: 10.1016/j.ddmod.2017.02.003. Epub 2017 Mar 31. PMID: 28983321; PMCID: PMC5624716.