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Beyond the skin: investigating psoriasis, its systemic associations, and the future of therapeutics
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Spring 2025
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2025-05
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Amjad_Honors.pdf
Adobe PDF, 3.99 MB
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This paper will highlight critical genetic factors that contribute to the phenotypes associated with psoriasis, examine potential causes, comorbidities, and currently available treatment options, and discuss future treatments in development. First, as psoriasis is an autoimmune disease, an examination of the immune system will be presented, along with a discussion of common causes and concerns, associated treatments, and future outcomes. The skin is the largest organ of the body. While many perceive skin disorders as cosmetic issues, this thesis aims to provide information that helps readers regard these conditions as serious problems affecting overall well-being rather than superficial concerns.
Key words: Psychobiology, Psoriasis, Immune System, Cytokines, Interleukins, JAK/STAT pathway, Nuclear factor kappa B (NF-κB), Biologics, Monoclonal Antibodies, Artificial Intelligence
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