Loading...
Clinical experience and results of a Sentinel Health Investigation related to indoor fungal exposure.
Journal Title
Environmental Health Perspectives
Keywords
Readers/Advisors
Journal Title
Term and Year
Publication Date
1999-06
Book Title
Publication Volume
107
Publication Issue
suppl 3
Publication Begin
489
Publication End
494
Number of pages
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
This is a review of exposure conditions, clinical presentation, and morbidity of children and adults with indoor fungal exposure such as toxic Stachybotrys chartarum. Indoor exposure was characterized using different methods including microscopic, culture, cytotoxicity screening tests, and chemical analyses. Clinical case histories and physical and laboratory findings are presented of children (age < 18 years, n = 22; mean age 9 years; 60% females) and adults (age >18 years, n = 125; mean age 39 years, 67% females) who consulted an environmental health specialty clinic. In the pediatric patients' exposure history, widespread fungal contamination of water-damaged building materials with known toxic or allergic fungi was identified. Primarily disorders of the respiratory system, skin, mucous membranes, and central nervous system were reported. Some enumeration and functional laboratory abnormalities, mainly of the lymphatic blood cells, were observed, although no statistically significant differences were found. IgE or IgG fungi-specific antibodies, used as exposure markers, were positive in less than 25% of all tested cases. In an evaluation of a symptomatic girl 11 years of age (sentinel case investigation) living in an apartment with verified toxigenic fungi (i.e., S. chartarum), several health indicators showed improvement after exposure cessation.
Citation
Johanning E, Landsbergis P, Gareis M, Yang CS, Olmsted E. Clinical experience and results of a Sentinel Health Investigation related to indoor fungal exposure. Environ Health Perspect. 1999 Jun;107 Suppl 3(Suppl 3):489-94. doi: 10.1289/ehp.99107s3489. PMID: 10346997; PMCID: PMC1566219.