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Nonlinear-dynamical arrhythmia control in humans
Journal Title
Proceedings of the National Academy of Sciences
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Publication Date
2001-04-24
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Publication Volume
98
Publication Issue
10
Publication Begin
5827
Publication End
5832
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Abstract
Nonlinear-dynamical control techniques, also known as chaos control, have been used with great success to control a wide range of physical systems. Such techniques have been used to control the behavior of in vitro excitable biological tissue, suggesting their potential for clinical utility. However, the feasibility of using such techniques to control physiological processes has not been demonstrated in humans. Here we show that nonlinear-dynamical control can modulate human cardiac electrophysiological dynamics by rapidly stabilizing an unstable target rhythm. Specifically, in 52/54 control attempts in five patients, we successfully terminated pacing-induced period-2 atrioventricular-nodal conduction alternans by stabilizing the underlying unstable steady-state conduction. This proof-of-concept demonstration shows that nonlinear-dynamical control techniques are clinically feasible and provides a foundation for developing such techniques for more complex forms of clinical arrhythmia.
Citation
Christini DJ, Stein KM, Markowitz SM, Mittal S, Slotwiner DJ, Scheiner MA, Iwai S, Lerman BB. Nonlinear-dynamical arrhythmia control in humans. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5827-32. doi: 10.1073/pnas.091553398. Epub 2001 Apr 24. PMID: 11320216; PMCID: PMC33298.