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Effects of regulatory BC1 RNA deletion on synaptic plasticity, learning, and memory
Journal Title
Learning & Memory
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Publication Date
2017-11-15
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24
Publication Issue
12
Publication Begin
646
Publication End
649
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ChungLM045617.pdf
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Abstract
Nonprotein coding dendritic BC1 RNA regulates translation of mRNAs in neurons. We examined two lines of BC1 knockout mice and report that loss of BC1 RNA exaggerates group I mGluR-stimulated LTD of the Schaffer collateral synapse, with one of the lines showing a much more enhanced DHPG-induced LTD than the other. When the animals were given the hippocampus-synaptic plasticity-dependent active place avoidance task, learning and memory were impaired in the BC1-KO line with the more severely altered DHPG-induced LTD. These findings indicate a role for BC1 RNA control of mGluR-dependent synaptic function in hippocampus and associated cognitive ability.
Citation
Chung A, Dahan N, Alarcon JM, Fenton AA. Effects of regulatory BC1 RNA deletion on synaptic plasticity, learning, and memory. Learn Mem. 2017 Nov 15;24(12):646-649. doi: 10.1101/lm.045617.117. PMID: 29142061; PMCID: PMC5688958.