Loading...
Gene-Environment Interplay: Where We Are, Where We Are Going.
Journal Title
Journal of marriage and the family
Readers/Advisors
Journal Title
Term and Year
Publication Date
Book Title
Publication Volume
77
Publication Issue
2
Publication Begin
344
Publication End
350
Number of pages
Collections
Files
Loading...
nihms651273.pdf
Adobe PDF, 141.48 KB
Research Projects
Organizational Units
Journal Issue
Abstract
The idea that both genetic and environmental influences contribute to behavioral outcomes is widely accepted. However, the practice of examining candidate Gene × Environment interaction (cGxE) is controversial. In this article, we summarize some of the key issues involved in cGxE research and provide recommendations for work in this area. Highlighted challenges include the selection of the gene, the development of the cGxE hypothesis, and the coding of the genotype. To address these challenges and gain confidence in cGxE findings, we recommend using empirical data to select and code genes/variants, using theory to develop cGxE hypotheses and a rigorous and transparent approach to hypothesis testing. Family researchers have much to offer to the study of Gene × Environment research in view of their process-oriented theories that are grounded in decades of nuanced measurement of the environment; implementing these best practices will help deliver on that promise.
Citation
Salvatore JE, Dick DM. Gene-Environment Interplay: Where We Are, Where We Are Going. J Marriage Fam. 2015 Apr;77(2):344-350. doi: 10.1111/jomf.12164. PMID: 25838604; PMCID: PMC4378262.