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Sophorolipids as antibacterial agents.
Journal Title
Annals of clinical and laboratory science
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2009
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39
Publication Issue
1
Publication Begin
60
Publication End
3
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60.full.pdf
Adobe PDF, 529.55 KB
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Abstract
Sophorolipids (SLs), glycolipids produced by yeasts, have been reported to have immunomodulating activity and to reduce the mortality rate in animal models of sepsis. In the present study, the antibacterial activities of SLs and several derivatives were tested against a selection of standard bacterial isolates using the broth microdilution method. The SL derivatives tested did not show any significant antibacterial activity in vitro when tested at clinically relevant concentrations. Most likely the reported decrease of mortality rate in the rat septic shock model was not secondary to antibacterial activity of SLs. The SLs may be used as anti-inflammatory agents or immunomodulators without affecting the host's bacterial flora.
Citation
Sleiman JN, Kohlhoff SA, Roblin PM, Wallner S, Gross R, Hammerschlag MR, Zenilman ME, Bluth MH. Sophorolipids as antibacterial agents. Ann Clin Lab Sci. 2009 Winter;39(1):60-3. PMID: 19201743.