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Investigating the antifungal potential of sertraline in Rhodotorula mucilaginosa
Leiva, Gabriela M.
Leiva, Gabriela M.
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Middleton, Elizabeth
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2025
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Fungal infections caused by antimicrobial-resistant strains are a growing clinical concern. This project explores the antifungal potential of sertraline, an SSRI, against Rhodotorula mucilaginosa, an emerging opportunistic yeast. Using a broth macrodilution assay, sertraline was found to inhibit growth at 32–64 ppm and exhibited fungicidal activity at 128 ppm. The MFC/MIC ratio (2–4) suggests fungicidal properties. While effective only at high concentrations, these findings highlight sertraline's potential as a repurposed antifungal agent.
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