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Exploring Sphingolipid Metabolism: Focus on Serine Palmitoyltransferase (SPT) and Therapeutic Implications of Targeting SPTLC3
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Jiang, Xian-Cheng
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Spring 2024
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2024-03-28
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Abstract
Sphingolipids perform vital functions in diverse cellular processes and contribute significantly to
the development and functionality of organs. This scientific review provides an overview of
sphingolipid metabolism, focusing on the synthesis, degradation, and the role of key enzymes
such as serine palmitoyltransferase (SPT). The synthetic pathway, which includes enzymes such
as 3-ketosphinganine reductase and dihydroceramide desaturase, facilitates the generation of
intricate sphingolipids from ceramide. Sphingolipid degradation, particularly within the
lysosomal compartment, is essential for cellular homeostasis. The scientific review emphasizes
the importance of SPT in regulating sphingolipid levels, with specific insights into its activity in
different tissues. Furthermore, it delves into the role of SPT in the liver and provides an
understanding of the architecture and function of SPTLC3. The paper concludes by highlighting
the potential therapeutic implications of targeting SPTLC3 and the need for further research in
this area.
Citation
Markopoulou, E. (2024). Exploring Sphingolipid Metabolism: Focus on Serine Palmitoyltransferase (SPT) and Therapeutic Implications of Targeting SPTLC3 [Masters Thesis, SUNY Downstate Health Sciences University]. SUNY Open Access Repository. https://soar.suny.edu/handle/20.500.12648/14780