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Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology.
Journal Title
Journal of pediatric gastroenterology and nutrition
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64
Publication Issue
2
Publication Begin
180
Publication End
185
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Abstract
The development of sustainable intestinal organoid cell culture has emerged as a new modality for the study of intestinal function and cellular processes. Organoid culture is providing a new testbed for therapeutic research and development. Intestinal organoids, self-renewing 3-dimensional structures comprised intestinal stem cells and their differentiated epithelial progeny allow for more facile and robust exploration of cellular activity, cell organization and structure, genetic manipulation, and vastly more physiologic modeling of intestinal response to stimuli as compared to traditional 2-dimensional cell line cultures. Intestinal organoids are affecting a wide variety of research into gastrointestinal pathology. The purpose of this review is to discuss the current state-of-the-art and future effect of research using enteroids and colonoids (organoids grown from the small and large intestines, respectively).
Citation
Wallach TE, Bayrer JR. Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology. J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):180-185. doi: 10.1097/MPG.0000000000001411. PMID: 27632431; PMCID: PMC5250540.