Antibiotic Resistance Caused by Class A Î²-Lactamases

The most effective and most used antibiotics for treating infections are known as beta-lactams. Unfortunately, more and more bacteria are developing different ways to fight against these antibiotics. The most common causes of resistance involve the creation of Î²-lactamase, which allows hydrolysis of the Î²-lactam ring, which results in the inactivation of the drug. A way around this is using Î²-lactamase inhibitors like clavulanic acid, sulbactam and tazobactam in combination with Î²-lactams for treatment. But, there is still bacterial resistance that occurs with combination therapy and it keeps evolving, which results in people developing immunity to these medications. As a result, scientists are looking to find broad-spectrum Î²-lactamase inhibitors that successfully fight Î²-lactamases. (Eiamphungporn et al., 2018)

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Antibiotic Resistance Caused by Class A Î²-Lactamases

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