Journal Title
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Keywords
Cellular and Molecular Neuroscience
 Psychiatry and Mental health
 Genetics(clinical)
 ADHD; DAT1; parent of origin effect; VNTR
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2009
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9999B
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n/a
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n/a
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Upstate College of Medicine Scholarly Publications
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2010_Faraone_ADHD.pdf
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http://hdl.handle.net/20.500.12648/1868
Abstract
We [Hawi et al. (2005); Am J Hum Genet 77:958–965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3′-UTR VNTR. In the current investigation, we analyzed three new samples comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3′-UTR VNTR, respectively) of DAT1. In addition, a similar pattern of over-transmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal overtransmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon.
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DOI
10.1002/ajmg.b.30960
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