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Repeated exposure to polycyclic aromatic hydrocarbons and asthma: effect of seroatopy.
Jung, Kyung Hwa Yan, Beizhan Moors, Kathleen Chillrud, Steven N Perzanowski, Matthew S Whyatt, Robin M Hoepner, Lori
Goldstein, Inge Zhang, Bingzhi Camann, David
Jung, Kyung Hwa
Yan, Beizhan
Moors, Kathleen
Chillrud, Steven N
Perzanowski, Matthew S
Whyatt, Robin M
Goldstein, Inge
Zhang, Bingzhi
Camann, David
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Journal Title
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
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Publication Date
2012-08-15
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Publication Volume
109
Publication Issue
4
Publication Begin
249
Publication End
54
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Abstract
Background: Exposure to traffic-related air pollutants, including polycyclic aromatic hydrocarbons (PAHs), can induce asthma. However, the effects of early repeated PAH exposure over time on different asthma phenotypes have not been examined.
Objective: To assess associations between repeated PAH exposure, measured from prenatal personal and residential indoor monitors in children's homes, and asthma in an inner-city cohort.
Methods: Prenatal exposure was assessed by personal air monitoring during 48 hours and exposure at 5 to 6 years of age by 2-week residential monitoring in the Columbia Center for Children's Environmental Health cohort. PAH was dichotomized into pyrene (representative semivolatile PAH) and the sum of 8 nonvolatile PAHs. High exposure to each was defined as measures above the median at both repeated time points. Asthma and wheeze were determined by validated questionnaires at ages 5 to 6 years. Children with specific IgE levels greater than 0.35 IU/mL to any of 5 indoor allergens were considered seroatopic.
Results: Among all 354 children, repeated high exposure to pyrene was associated with asthma (odds ratio [OR], 1.90; 95% confidence interval [CI], 1.13-3.20). Among 242 nonatopic children, but not those sensitized to indoor allergens (n = 87) or with elevated total IgE levels (n = 171), high pyrene levels were associated positively with asthma (OR, 2.89; 95% CI, 1.77-5.69), asthma medication use (OR, 2.28; 95% CI, 1.13-4.59), and emergency department visits for asthma (OR, 2.43; 95% CI, 1.20-4.91). Associations between the levels of the 8 nonvolatile PAHs and asthma were not observed, even when stratifying by seroatopy.
Conclusion: Nonatopic children may be more susceptible to the respiratory consequences of early pyrene exposures.
Citation
Jung KH, Yan B, Moors K, Chillrud SN, Perzanowski MS, Whyatt RM, Hoepner L, Goldstein I, Zhang B, Camann D, Kinney PL, Perera FP, Miller RL. Repeated exposure to polycyclic aromatic hydrocarbons and asthma: effect of seroatopy. Ann Allergy Asthma Immunol. 2012 Oct;109(4):249-54. doi: 10.1016/j.anai.2012.07.019. Epub 2012 Aug 15. PMID: 23010230; PMCID: PMC3496175.