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Chronic depressive symptoms and Framingham coronary risk in HIV-infected and HIV-uninfected women
Schwartz, Rebecca M. Mansoor, Ather Wilson, Tracey E. Anastos, Kathryn Everson-Rose, Susan A. Golub, Elizabeth T. Goparaju, Lakshmi Hessol, Nancy A. Mack, Wendy J. Lazar, Jason
Schwartz, Rebecca M.
Mansoor, Ather
Wilson, Tracey E.
Anastos, Kathryn
Everson-Rose, Susan A.
Golub, Elizabeth T.
Goparaju, Lakshmi
Hessol, Nancy A.
Mack, Wendy J.
Lazar, Jason
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Journal Title
AIDS Care
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Term and Year
Publication Date
2011-09-09
Type
Book Title
Publication Volume
24
Publication Issue
3
Publication Begin
394
Publication End
403
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nihms323709.pdf
Adobe PDF, 336.28 KB
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Abstract
Depression is common in people with cardiovascular diseases (CVD) and those with HIV, and is a risk factor for CVD-related mortality. However, little is known about whether HIV influences the relationship between depression and cardiovascular risk. A total of 526 HIV-infected and 132 uninfected women from the Women's Interagency HIV Study were included in an analysis of women who completed twice-yearly study visits over 9.5 years. CVD risk was calculated at baseline and approximately 9.5 years later using the Framingham Risk Score (FRS). Chronic depressive symptoms were defined as Center for Epidemiologic Studies Depression Scale scores of 16 or greater at ≥75% of study visits. Over the follow-up period, 22.8% of HIV-infected women and 15.9% of HIV-uninfected women had chronic depressive symptoms (p=0.08). Baseline FRS was similar between HIV-infected and uninfected women (M=-5.70 ± SE=0.30 vs. M=-6.90 ± SE=0.60, p=0.07) as was follow-up FRS (M=0.82 ± SE=0.30 vs. M=-0.44 ± SE=0.73, p=0.11). Among HIV-infected and HIV-uninfected women, together, follow-up FRS was higher among women with chronic depressive symptoms as compared to those without (M=1.3 ± SE=0.6 vs. M=-0.3 ± SE=0.40, p<0.01), after adjusting for baseline FRS and other covariates. HIV status did not modify the relationship between chronic depressive symptoms and FRS. Chronic depressive symptoms accelerated CVD risk scores to a similar extent in both HIV-infected and-uninfected women. This implies that the diagnosis and treatment of depression may be an important consideration in CV risk reduction in the setting of HIV-infection. The determination of factors that mediate the depression/CVD relationship merits further study.
Citation
Schwartz RM, Mansoor A, Wilson TE, Anastos K, Everson-Rose SA, Golub ET, Goparaju L, Hessol NA, Mack WJ, Lazar J. Chronic depressive symptoms and Framingham coronary risk in HIV-infected and HIV-uninfected women. AIDS Care. 2012;24(3):394-403. doi: 10.1080/09540121.2011.608791. Epub 2011 Sep 9. PMID: 21902560; PMCID: PMC3243818.