Loading...
Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit.
Journal Title
PLoS computational biology
Keywords
Readers/Advisors
Journal Title
Term and Year
Publication Date
2023-03-23
Book Title
Publication Volume
19
Publication Issue
3
Publication Begin
e1010942
Publication End
Number of pages
Collections
Files
Loading...
journal.pcbi.1010942.pdf
Adobe PDF, 12.61 MB
Research Projects
Organizational Units
Journal Issue
Abstract
Phase amplitude coupling (PAC) between slow and fast oscillations is found throughout the brain and plays important functional roles. Its neural origin remains unclear. Experimental findings are often puzzling and sometimes contradictory. Most computational models rely on pairs of pacemaker neurons or neural populations tuned at different frequencies to produce PAC. Here, using a data-driven model of a hippocampal microcircuit, we demonstrate that PAC can naturally emerge from a single feedback mechanism involving an inhibitory and excitatory neuron population, which interplay to generate theta frequency periodic bursts of higher frequency gamma. The model suggests the conditions under which a CA1 microcircuit can operate to elicit theta-gamma PAC, and highlights the modulatory role of OLM and PVBC cells, recurrent connectivity, and short term synaptic plasticity. Surprisingly, the results suggest the experimentally testable prediction that the generation of the slow population oscillation requires the fast one and cannot occur without it.
Citation
Ponzi A, Dura-Bernal S, Migliore M. Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit. PLoS Comput Biol. 2023 Mar 23;19(3):e1010942. doi: 10.1371/journal.pcbi.1010942. Epub ahead of print. PMID: 36952558.