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Unraveling the Mystery of Non-Coding Genomic Content: Evolution, Regulation, and Functional Significance
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Christini, David
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Spring 2024
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2023-12-22
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Velez Thesis.pdf
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Abstract
This comprehensive review explores the diverse realm of non-coding genomic content,
shedding light on its crucial functions in intricate organisms. Once considered mere "junk DNA”,
non-coding genomic elements have now proven to be pivotal regulators in genetic coordination.
The primary focus of this review is centered around understanding the indispensability of noncoding
genomic content for complex organisms. To further unpack this, an in depth look of key
non-coding elements, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs),
small cytoplasmic RNAs (scRNAs), nucleolar RNAs (noRNAs) and transposable elements (TEs)
was done. The possible evolutionary and regulatory role of non-coding genomic content was also
explored. Specifically, gene regulatory network formation, and cell specific regulation.
Understanding these non-coding elements is pivotal not only for the understanding of
evolutionary biology, but for the development of our own precision medicine and innovative
strategies in fields like conservation and agriculture. The multifaceted functions of non-coding
DNA in complex organisms emphasizes its central significance in the intricate genetic
framework. Ultimately this genomic content serves as a fundamental and dynamic component of
the genomic landscape. This article intends to encourage additional research and allow for a
deeper appreciation for the role of non-coding genomic content in the realm of complex life
forms.
Citation
Velez, C. (2023). Unraveling the Mystery of Non-Coding Genomic Content: Evolution, Regulation, and Functional Significance [Masters Thesis, SUNY downstate Health Sciences University]. SUNY Open Access Repository. https://soar.suny.edu/handle/20.500.12648/14781