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A Brief Critique of the TATES Procedure.
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Behavior genetics
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2018-02-21
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48
Publication Issue
2
Publication Begin
155
Publication End
167
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nihms966814.pdf
Adobe PDF, 343.33 KB
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Abstract
The Trait-based test that uses the Extended Simes procedure (TATES) was developed as a method for conducting multivariate GWAS for correlated phenotypes whose underlying genetic architecture is complex. In this paper, we provide a brief methodological critique of the TATES method using simulated examples and a mathematical proof. Our simulated examples using correlated phenotypes show that the Type I error rate is higher than expected, and that more TATES p values fall outside of the confidence interval relative to expectation. Thus the method may result in systematic inflation when used with correlated phenotypes. In a mathematical proof we further demonstrate that the distribution of TATES p values deviates from expectation in a manner indicative of inflation. Our findings indicate the need for caution when using TATES for multivariate GWAS of correlated phenotypes.
Citation
Aliev F, Salvatore JE, Agrawal A, Almasy L, Chan G, Edenberg HJ, Hesselbrock V, Kuperman S, Meyers J, Dick DM. A Brief Critique of the TATES Procedure. Behav Genet. 2018 Mar;48(2):155-167. doi: 10.1007/s10519-018-9890-6. Epub 2018 Feb 21. PMID: 29468442; PMCID: PMC6028780.